Selected Publications

Stykel, MG, Humphries K, Kirby MP, Czaniecki C, Wang T, Ryan T, Bamm V and Ryan SD (2018). Nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of Parkinson's disease. The FASEB Journal. Apr 24:fj201700759RR. doi: 10.1096/fj.201700759RR.

*Profiled by The Canadian Press (May 2018)

Ryan T, Bamm VV, Stykel MG, Coackley CL, Humphries KM, Jamieson-Williams R, Ambasudhan R, Mosser DD, Lipton SA, Harauz G, Ryan SD (2018) Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein. Nat Commun. Feb 26;9(1):817. doi: 10.1038/s41467-018-03241-9.

*Profiled in Parkinson's News Today (March 1, 2018)

Tu S, Akhtar M, Escorheula RM, Amador-Arjona A, Swarup V, Parker J, Zaremba J, Holland T, Bansal N, Holohan D, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, Huang X, McKercher S, Ambasudhan R, Wang Y, Geschwind D, Roberts A, Terskikh A, Rissman RA, Masliah E, Lipton S, Nakanishi N. (2017). NitroSynapsin therapy for the mouse MEF2C haplo-insufficiency model of human autism. Nature Communications. Nov 14;8(1):1488. doi: 10.1038/s41467-017-01563-8.

Ryan SD, Dolatabadi N, Chan SF, Zhang X, Akhtar MW, Parker J, , Soldner F, Sunico CR, Nagar S, Talantova M, Lee B, Lopez K, Nutter A, Shan B, Molokanova E, Zhang Y, Han X, Masliah E, Yates JR, Nakanishi N, Andreyev A, Okamoto S, Jaenisch R, Ambasudhan R, Lipton SA (2013) Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription. CELL, Dec 5:155(6) 1351.

*Profiled by Amanda Woerner, FOX News (Nov 27, 2013)

Nakanichi N, Ryan SD, Holland T, Cho EG, Liao F-F, Xu X, Lipton SA, Tu S (2012) Synaptic protein α1-takusan mitigates Aβ-induced synaptic loss via its interaction with PSD-95 and tau at postsynaptic sites.  J. Neurosci,Aug 28;33(35):14170-83

Piña-Crespo JC, Talantova M, Cho EG, Soussou W, Dolatabadi N, Ryan SD, Ambasudhan R, McKercher S, Deisseroth K, Lipton SA (2012) High-frequency hippocampal oscillations activated by optogenetic stimulation of transplanted human ESC-derived neurons.J. Neurosci Nov 7;32(45):15837-42

*Profiled in ScienceDaily, (Nov. 15, 2012)

Ryan SD, Bhanot K, Ferrier A, De Repentingy Y, Chu A, Blais A, Kothary R (2012) Microtubule stability, Golgi organization, and transport flux require dystonin-a2/MAP1B interaction. J. Cell Biol. Mar;196(6)

*Profiled in NewsRx (April 20th 2012)

Ryan SD, Ferrier A, Sato T, O’Meara RW, De Repentingy Y, Jiang SX, Hou ST, Kothary R (2011) Neuronal dystonin isoform 2 is a novel mediator of endoplasmic reticulum structure and function. Mol Biol Cell, Feb;23(4):553-66

O’Meara RW, Ryan SD, Colognato H, Kothary R (2011) Derivation of enriched oligodendrocyte cultures and oligodendrocyte/neuron myelinating co-cultures from post-natal murine tissues. Journal of Visual Experimentation (JOVE) Aug 21;(54). pii: 3324. doi: 10.3791/3324

Ryan SD, Whitehead, SN, Swayne L, Moffat, TC, Hou W, Ethier M, Bourgeois AJG, Rashidian J, Fraser PE, Figeys D, Park DS, Bennett SAL  (2009) Disruption of alkylacylglycerophosphocholines by amyloid-b42 signals tau hyperphosphorylation and compromises neuronal viability.  PNAS, Dec 8;106(49):20936-41

*Profiled in Alzheimer Research Forum (Nov 22, 2009) *Profiled in CrossBorder Biotech. (Nov 27 2009)